Idarucizumab for Dabigatran Reversal — Full Cohort Analysis

Idarucizumab was 100% effective in reversing the anticoagulant effect of dabigatran among 300 patients with uncontrolled bleeding (median time to bleeding cessation, 2.5 hours) and among 200 patients who required an urgent procedure (median time to procedure initiation, 1.6 hours).

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Bibliographische Detailangaben
Veröffentlicht in:	The New England journal of medicine 2017-08, Vol.377 (5), p.431-441
Hauptverfasser:	Pollack, Charles V, Reilly, Paul A, van Ryn, Joanne, Eikelboom, John W, Glund, Stephan, Bernstein, Richard A, Dubiel, Robert, Huisman, Menno V, Hylek, Elaine M, Kam, Chak-Wah, Kamphuisen, Pieter W, Kreuzer, Jörg, Levy, Jerrold H, Royle, Gordon, Sellke, Frank W, Stangier, Joachim, Steiner, Thorsten, Verhamme, Peter, Wang, Bushi, Young, Laura, Weitz, Jeffrey I
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Aged, 80 and over Antibodies - blood Antibodies, Monoclonal, Humanized - adverse effects Antibodies, Monoclonal, Humanized - immunology Antibodies, Monoclonal, Humanized - therapeutic use Anticoagulants Anticoagulants - adverse effects Bleeding Blood Coagulation - drug effects Clotting Cohort analysis Dabigatran - adverse effects Dabigatran - antagonists & inhibitors Dabigatran - blood Drug dosages Drug Hypersensitivity Drug therapy Female Hemorrhage Hemorrhage - chemically induced Hemorrhage - drug therapy Hemostasis Humans Infusions, Intravenous Intravenous administration Male Middle Aged Monoclonal antibodies Mortality Patients Preventive medicine Prospective Studies Surgery Thrombin Thrombin Time Thrombosis Thrombosis - chemically induced Time Factors
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Beschreibung
Zusammenfassung:	Idarucizumab was 100% effective in reversing the anticoagulant effect of dabigatran among 300 patients with uncontrolled bleeding (median time to bleeding cessation, 2.5 hours) and among 200 patients who required an urgent procedure (median time to procedure initiation, 1.6 hours).
ISSN:	0028-4793 1533-4406
DOI:	10.1056/NEJMoa1707278