Synthesis and characterization of new pyrazolyl-substituted thiazolidinone, thiazole, and thiazoline candidates

Synthesis and characterization of new pyrazolyl-substituted thiazolidinone, thiazole, and thiazoline candidates

1-(3-Chlorophenyl)-3-(4-methoxyphenyl)-1 H -pyrazole-4-carbaldehyde was used in preparation of ( E )-1-{[1-(3-chlorophenyl)-3-(4-methoxyphenyl)-1 H -pyrazol-4-yl]methylene}thiosemicarbazide. Its following reaction with ethyl bromoacetate, diethyl 2-bromomalonate, phenacyl bromide, and maleic anhydri...

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Veröffentlicht in:Russian journal of general chemistry 2017-06, Vol.87 (6), p.1295-1299
Hauptverfasser: Khalifa, N. M., Nossier, E. S., Al-Omar, M. A.
Format: Artikel
Sprache:eng
Schlagworte:
Chemistry
Chemistry and Materials Science
Chemistry/Food Science
Maleic anhydride
Methylene
Pharmacology
Pyrazole
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Zusammenfassung:1-(3-Chlorophenyl)-3-(4-methoxyphenyl)-1 H -pyrazole-4-carbaldehyde was used in preparation of ( E )-1-{[1-(3-chlorophenyl)-3-(4-methoxyphenyl)-1 H -pyrazol-4-yl]methylene}thiosemicarbazide. Its following reaction with ethyl bromoacetate, diethyl 2-bromomalonate, phenacyl bromide, and maleic anhydride gave pyrazolyl pharmacophore linked thiazole, thiazoline and thiazolidinone-5-carboxylic acid derivatives.
ISSN:1070-3632
1608-3350
DOI:10.1134/S1070363217060263