Molecular Magnetic Resonance Imaging of Lung Fibrogenesis with an Oxyamine‐Based Probe

Fibrogenesis is the active production of extracellular matrix in response to tissue injury. In many chronic diseases persistent fibrogenesis results in the accumulation of scar tissue, which can lead to organ failure and death. However, no non‐invasive technique exists to assess this key biological process. All tissue fibrogenesis results in the formation of allysine, which enables collagen cross‐linking and leads to tissue stiffening and scar formation. We report herein a novel allysine‐binding gadolinium chelate (GdOA), that can non‐invasively detect and quantify the extent of fibrogenesis using magnetic resonance imaging (MRI). We demonstrate that GdOA signal enhancement correlates with the extent of the disease and is sensitive to a therapeutic response. Ein Hauptmerkmal der Fibrogenese ist die Oxidation von Lysinresten auf Collagen zu Allysin, das verantwortlich für die Collagenvernetzung, Fibrillenbildung und Ablagerung von Narbengewebe bei fibrotischen Erkrankungen ist. Die Sonde GdOA bindet an Allysin, wobei sie dessen MRI‐Signal in einem Modell für fibrotische Lungenerkrankungen erhöht und eine quantitative Bestimmung der Fibrogenese ermöglicht.