Development and Evaluation of drug loaded Eudragit RS-100 microspheres for colon specific drug delivery system

In the present study attempt was made for colon specific drug delivery using Eudragit RS100 microspheres of Serratiopeptidase an analgesic and anti-inflammatory activities,.Eudragit RS100 microspheres of Serratiopeptidase were prepared by solvent evaporation technique using Eudragit RS100 as a rate...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:The pharma innovation 2014-02, Vol.2 (12, Part A), p.67
Hauptverfasser: Hire, N N, Derle, D V
Format: Artikel
Sprache:eng
Schlagworte:
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
container_end_page
container_issue 12, Part A
container_start_page 67
container_title The pharma innovation
container_volume 2
creator Hire, N N
Derle, D V
description In the present study attempt was made for colon specific drug delivery using Eudragit RS100 microspheres of Serratiopeptidase an analgesic and anti-inflammatory activities,.Eudragit RS100 microspheres of Serratiopeptidase were prepared by solvent evaporation technique using Eudragit RS100 as a rate controlling polymer and the microspheres were evaluated. Eudragit RS100 microspheres were spherical, discrete, free flowing and multinucleate monolithic type. The mean size range was found for formulation in the range of 31 to 33 μm. Entrapment efficiency was in the range of 83.827 to 95.407 %. The FTIR and DSC study confirmed that no chemical interaction took place during entrapment process. The X-ray diffraction study indicates the amorphous dispersion of the drug after entrapment in to microspheres. The effect of polymer on release profile of drug was calculated. Serratiopeptidaserelease from theEudragit RS100 microspheres was slow over 12 hr and dependant on core: coat ratio and size of microspheres. Drug release was by higuchi mechanism. Good linear relationship were observed between core : coat ratio of the microspheres and release rate.Eudragit RS100microspheres of Serratiopeptidase exhibited good controlled release characteristics and were found suitable for once a day oral controlled release products.
format Article
fullrecord <record><control><sourceid>proquest</sourceid><recordid>TN_cdi_proquest_journals_1924684196</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1924684196</sourcerecordid><originalsourceid>FETCH-proquest_journals_19246841963</originalsourceid><addsrcrecordid>eNqNi8sKwjAQRYMgKOo_DLgu9GVr1j5wre4lNFONpJmaSQr-vQX9AO_mLs45EzHP87pO6kpuZmLF_EzHSVkUuZwLt8cBLfUdugDKaTgMykYVDDmgFrSPd7CkNI4kaq_uJsD5kmRpCp1pPHH_QI8MLXloyI4V99iY1jTfVqM1A_o38JsDdksxbZVlXP1-IdbHw3V3SnpPr4gcbk-K3o3olsm8rLZlJqviP-sDFSVJ_Q</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1924684196</pqid></control><display><type>article</type><title>Development and Evaluation of drug loaded Eudragit RS-100 microspheres for colon specific drug delivery system</title><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><creator>Hire, N N ; Derle, D V</creator><creatorcontrib>Hire, N N ; Derle, D V</creatorcontrib><description>In the present study attempt was made for colon specific drug delivery using Eudragit RS100 microspheres of Serratiopeptidase an analgesic and anti-inflammatory activities,.Eudragit RS100 microspheres of Serratiopeptidase were prepared by solvent evaporation technique using Eudragit RS100 as a rate controlling polymer and the microspheres were evaluated. Eudragit RS100 microspheres were spherical, discrete, free flowing and multinucleate monolithic type. The mean size range was found for formulation in the range of 31 to 33 μm. Entrapment efficiency was in the range of 83.827 to 95.407 %. The FTIR and DSC study confirmed that no chemical interaction took place during entrapment process. The X-ray diffraction study indicates the amorphous dispersion of the drug after entrapment in to microspheres. The effect of polymer on release profile of drug was calculated. Serratiopeptidaserelease from theEudragit RS100 microspheres was slow over 12 hr and dependant on core: coat ratio and size of microspheres. Drug release was by higuchi mechanism. Good linear relationship were observed between core : coat ratio of the microspheres and release rate.Eudragit RS100microspheres of Serratiopeptidase exhibited good controlled release characteristics and were found suitable for once a day oral controlled release products.</description><identifier>EISSN: 2277-7695</identifier><language>eng</language><publisher>New Delhi: The Pharma Innovation</publisher><subject>Drug delivery systems</subject><ispartof>The pharma innovation, 2014-02, Vol.2 (12, Part A), p.67</ispartof><rights>Copyright The Pharma Innovation Feb 2014</rights><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780</link.rule.ids></links><search><creatorcontrib>Hire, N N</creatorcontrib><creatorcontrib>Derle, D V</creatorcontrib><title>Development and Evaluation of drug loaded Eudragit RS-100 microspheres for colon specific drug delivery system</title><title>The pharma innovation</title><description>In the present study attempt was made for colon specific drug delivery using Eudragit RS100 microspheres of Serratiopeptidase an analgesic and anti-inflammatory activities,.Eudragit RS100 microspheres of Serratiopeptidase were prepared by solvent evaporation technique using Eudragit RS100 as a rate controlling polymer and the microspheres were evaluated. Eudragit RS100 microspheres were spherical, discrete, free flowing and multinucleate monolithic type. The mean size range was found for formulation in the range of 31 to 33 μm. Entrapment efficiency was in the range of 83.827 to 95.407 %. The FTIR and DSC study confirmed that no chemical interaction took place during entrapment process. The X-ray diffraction study indicates the amorphous dispersion of the drug after entrapment in to microspheres. The effect of polymer on release profile of drug was calculated. Serratiopeptidaserelease from theEudragit RS100 microspheres was slow over 12 hr and dependant on core: coat ratio and size of microspheres. Drug release was by higuchi mechanism. Good linear relationship were observed between core : coat ratio of the microspheres and release rate.Eudragit RS100microspheres of Serratiopeptidase exhibited good controlled release characteristics and were found suitable for once a day oral controlled release products.</description><subject>Drug delivery systems</subject><issn>2277-7695</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>BENPR</sourceid><recordid>eNqNi8sKwjAQRYMgKOo_DLgu9GVr1j5wre4lNFONpJmaSQr-vQX9AO_mLs45EzHP87pO6kpuZmLF_EzHSVkUuZwLt8cBLfUdugDKaTgMykYVDDmgFrSPd7CkNI4kaq_uJsD5kmRpCp1pPHH_QI8MLXloyI4V99iY1jTfVqM1A_o38JsDdksxbZVlXP1-IdbHw3V3SnpPr4gcbk-K3o3olsm8rLZlJqviP-sDFSVJ_Q</recordid><startdate>20140201</startdate><enddate>20140201</enddate><creator>Hire, N N</creator><creator>Derle, D V</creator><general>The Pharma Innovation</general><scope>04Q</scope><scope>04S</scope><scope>04W</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope></search><sort><creationdate>20140201</creationdate><title>Development and Evaluation of drug loaded Eudragit RS-100 microspheres for colon specific drug delivery system</title><author>Hire, N N ; Derle, D V</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-proquest_journals_19246841963</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Drug delivery systems</topic><toplevel>online_resources</toplevel><creatorcontrib>Hire, N N</creatorcontrib><creatorcontrib>Derle, D V</creatorcontrib><collection>India Database</collection><collection>India Database: Business</collection><collection>India Database: Science &amp; Technology</collection><collection>ProQuest Central (Corporate)</collection><collection>Health &amp; Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health &amp; Medical Complete (Alumni)</collection><collection>Health &amp; Medical Collection (Alumni Edition)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><jtitle>The pharma innovation</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hire, N N</au><au>Derle, D V</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Development and Evaluation of drug loaded Eudragit RS-100 microspheres for colon specific drug delivery system</atitle><jtitle>The pharma innovation</jtitle><date>2014-02-01</date><risdate>2014</risdate><volume>2</volume><issue>12, Part A</issue><spage>67</spage><pages>67-</pages><eissn>2277-7695</eissn><abstract>In the present study attempt was made for colon specific drug delivery using Eudragit RS100 microspheres of Serratiopeptidase an analgesic and anti-inflammatory activities,.Eudragit RS100 microspheres of Serratiopeptidase were prepared by solvent evaporation technique using Eudragit RS100 as a rate controlling polymer and the microspheres were evaluated. Eudragit RS100 microspheres were spherical, discrete, free flowing and multinucleate monolithic type. The mean size range was found for formulation in the range of 31 to 33 μm. Entrapment efficiency was in the range of 83.827 to 95.407 %. The FTIR and DSC study confirmed that no chemical interaction took place during entrapment process. The X-ray diffraction study indicates the amorphous dispersion of the drug after entrapment in to microspheres. The effect of polymer on release profile of drug was calculated. Serratiopeptidaserelease from theEudragit RS100 microspheres was slow over 12 hr and dependant on core: coat ratio and size of microspheres. Drug release was by higuchi mechanism. Good linear relationship were observed between core : coat ratio of the microspheres and release rate.Eudragit RS100microspheres of Serratiopeptidase exhibited good controlled release characteristics and were found suitable for once a day oral controlled release products.</abstract><cop>New Delhi</cop><pub>The Pharma Innovation</pub></addata></record>
fulltext fulltext
identifier EISSN: 2277-7695
ispartof The pharma innovation, 2014-02, Vol.2 (12, Part A), p.67
issn 2277-7695
language eng
recordid cdi_proquest_journals_1924684196
source Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals
subjects Drug delivery systems
title Development and Evaluation of drug loaded Eudragit RS-100 microspheres for colon specific drug delivery system
url https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-17T04%3A27%3A34IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Development%20and%20Evaluation%20of%20drug%20loaded%20Eudragit%20RS-100%20microspheres%20for%20colon%20specific%20drug%20delivery%20system&rft.jtitle=The%20pharma%20innovation&rft.au=Hire,%20N%20N&rft.date=2014-02-01&rft.volume=2&rft.issue=12,%20Part%20A&rft.spage=67&rft.pages=67-&rft.eissn=2277-7695&rft_id=info:doi/&rft_dat=%3Cproquest%3E1924684196%3C/proquest%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1924684196&rft_id=info:pmid/&rfr_iscdi=true