Regioselective synthesis of some new 1,4-disubstituted sulfonyl-1,2,3-triazoles and their antibacterial activity studies

Some new 1,4-disubstituted-sulfonyl-1,2,3-triazoles ( 3a – f , 5a – h , 7a – d , and 9a – e ) were regioselectively synthesized in high yields by Cu(I) catalyzed 1,3-dipolar cycloaddition (DC) reaction of p -acetamidobenzenesulfonyl azide ( p -ABSA) with terminal alkynes. These new triazole compounds were evaluated for in vitro antibacterial activity against a panel of Gram-positive Bacillus sphericus, Staphylococcus epidermidis , and Gram-negative Klebsiella pneumonia, Escherichia coli species. Several of these compounds were found to possess comparable growth inhibition activity with the commercial standards Penicillin-G and Streptomycin.