The current state and development of perspectives of application of synthetic antimicrobial agents

The review presents data regarding the main classes of substances applied in pharmaceutics for long-term control of pathogenic microflora. The problems of application of these substances caused by the resistance of pathogenic microflora to the main classes of the biocides are discussed. Mechanisms of action of antimicrobial agents and possible mechanisms of adaptation of pathogenic microflora to these substances are considered. Guanidine-containing cationic polyelectrolytes with different structures affecting their features, as well as the main stages of their mechanism of action, are described. Comparative information on the range of antimicrobial action of representatives of this class based on the results of studies conducted in different periods of time is presented. Analysis of the literature data demonstrated that branched oligohexamethyleneguanidine hydrochloride is a promising compound for the development of pharmaceutical substance.