The effects of a topical lipid complex therapy on dogs with atopic dermatitis: a double blind, randomized, placebo-controlled study

Background Canine atopic dermatitis is a common clinical presentation. The skin barrier seems to play a fundamental role in the pathogenesis. Therefore a topical spot-on product containing a mixture of lipids may improve clinical signs without adverse effects if it were to improve stratum corneum barrier function. Animals Twenty six privately owned atopic dogs of different breed, age, gender and weight were included in a double blind, randomized, placebo-controlled study. Hypothesis/Objectives To evaluate potential clinical benefits and influence on skin barrier function of a topical lipid-containing product applied to the skin of atopic dogs. Methods and results Atopic dermatitis was diagnosed by adequate testing and the exclusion of other possible pruritic diseases. Dogs were randomly allocated to two treatment groups. A spot-on product containing different types of lipids was applied twice weekly to predisposed and affected areas. The placebo preparation contained only the excipients. The clinical effects were regularly verified with a Visual Analog Score and the Canine Atopic Dermatitis Extent and Severity Index. A medication score was calculated and barrier function was evaluated by means of transepidermal water loss and pH measurements. Twenty three dogs completed the study. There were no significant differences between the groups for any of the evaluated parameters. Adverse effects were not noted. Conclusions and clinical importance This study could not confirm significant clinical improvement when using the product compared to the placebo, although its use was not associated with adverse effects. Résumé Contexte La dermatite atopique canine est une présentation clinique fréquente. La barrière cutanée semble jouer un rôle fondamental dans la pathogénie. Ainsi un spot-on topique contenant un mélange de lipides peut améliorer les signes cliniques sans effet secondaire en améliorant la fonction barrière cutanée. Sujets Vingt-six chiens atopiques de différentes races, âges, genre et poids ont été inclus dans une étude en double aveugle, randomisée contre placebo. Hypothèses/Objectifs Estimer les bénéfices potentiels et l'influence sur la barrière cutanée d'un produit topique contenant des lipides appliqués sur la peau de chiens atopiques. Méthodes et résultats La dermatite atopique a été diagnostiquée par des tests appropriés et l'exclusion d'autres dermatoses prurigineuses. Les chiens ont été répartis au hasard dans deux groupes de traitement. Un produ