Triflic Acid Catalyzed 1,6‐Conjugate Addition of Thiols to p‐Quinone Methides under Continuous‐Flow Conditions

A simple and efficient protocol to access diarylmethyl thioethers through the triflic acid catalyzed vinylogous Michael addition of aromatic and aliphatic thiols to p‐quinone methides under continuous‐flow conditions by using a microreactor was developed. A 100 % atom‐efficient continuous‐flow proto...

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Veröffentlicht in:	European journal of organic chemistry 2017-07, Vol.2017 (25), p.3716-3721
Hauptverfasser:	Jadhav, Abhijeet S., Anand, Ramasamy Vijaya
Format:	Artikel
Sprache:	eng
Schlagworte:	Aliphatic compounds Conjugate addition Continuous flow Michael addition Microreactors Sulfur Thiols Triflic acid
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Beschreibung
Zusammenfassung:	A simple and efficient protocol to access diarylmethyl thioethers through the triflic acid catalyzed vinylogous Michael addition of aromatic and aliphatic thiols to p‐quinone methides under continuous‐flow conditions by using a microreactor was developed. A 100 % atom‐efficient continuous‐flow protocol to access diarylmethyl thioethers through the triflic acid (TfOH) catalyzed 1,6‐conjugate addition of thiols to p‐quinone methides by using microreactor technology is developed.
ISSN:	1434-193X 1099-0690
DOI:	10.1002/ejoc.201700587