Pharmacokinetic Modeling and Simulation Analysis of LCB01-0371, A New Oxazolidinone Antibiotic Under Clinical Development

Pharmacokinetic Modeling and Simulation Analysis of LCB01-0371, A New Oxazolidinone Antibiotic Under Clinical Development

The aims of this study were to develop a population pharmacokinetics (PPK) model for oral LCB01-0371 in healthy Korean volunteers and to predict the plasma LCB01-0371 concentration over time on various dosing regimens of LCB01-0371 via Monte-Carlo simulation Methods Pharmacokinetics (PK) data were c...

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Veröffentlicht in:Clinical therapeutics 2017-08, Vol.39 (8), p.e52-e52
Hauptverfasser: Cho, Y.-S, Kim, Y. Han, Choi, H. Youn, Kim, Y. Zu, Cho, Y. Lag, Nam, H. Sook, Bae, K.-S, Lim, H.-S
Format: Artikel
Sprache:eng
Schlagworte:
Antibiotics
Computer simulation
Internal Medicine
Medical Education
Monte Carlo simulation
Pharmacokinetics
Pharmacology
Plasma
Simulation
Simulation analysis
Urine
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Zusammenfassung:The aims of this study were to develop a population pharmacokinetics (PPK) model for oral LCB01-0371 in healthy Korean volunteers and to predict the plasma LCB01-0371 concentration over time on various dosing regimens of LCB01-0371 via Monte-Carlo simulation Methods Pharmacokinetics (PK) data were collected from 110 healthy, Korean, male subjects...
ISSN:0149-2918
1879-114X
DOI:10.1016/j.clinthera.2017.05.161