Variability of The Drug Response To Nsaids According To Cox-2 Genetic Polymorphism

Background Non-steroidal anti-inflammatory drugs (NSAIDs) are the most widely prescribed pharmaceutical agents worldwide, and cyclooxygenase (COX) is the main pharmacodynamic target of NSAIDs. Pharmacodynamic comparisons of celecoxib genotypes after single oral administration of 200 mg celecoxib Con...

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Veröffentlicht in:Clinical therapeutics 2017-08, Vol.39 (8), p.e27-e27
Hauptverfasser: Park, M. Kyu, Kim, S. Beom, Choi, Y. Sim, Park, S. Rin, Kim, J.-W, Lee, S. Joung
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Sprache:eng
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Zusammenfassung:Background Non-steroidal anti-inflammatory drugs (NSAIDs) are the most widely prescribed pharmaceutical agents worldwide, and cyclooxygenase (COX) is the main pharmacodynamic target of NSAIDs. Pharmacodynamic comparisons of celecoxib genotypes after single oral administration of 200 mg celecoxib Conclusions The inhibitory effects of celecoxib on COX-2 induction were different according to the genotype of COX-2 SNPs, and the results of the present study indicated that rs689466 is responsible for the variability of the response to NSAIDs, including...
ISSN:0149-2918
1879-114X
DOI:10.1016/j.clinthera.2017.05.083