ADME Gene Regulation Through miRNA – Role of Inflammation

ADME Gene Regulation Through miRNA – Role of Inflammation

Methods We characterized the acute phase response in human liver by genomewide RNA and miRNA profiling of livers from donors with elevated versus normal levels of the inflammation marker C-reactive protein. In particular miR-130b was shown to be upregulated in inflammation and to downregulate the en...

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Veröffentlicht in:Clinical therapeutics 2017-08, Vol.39 (8), p.e109-e110
Hauptverfasser: Zanger, U.M, Kugler, N, Klein, K
Format: Artikel
Sprache:eng
Schlagworte:
C-reactive protein
Cytochromes
Enzymatic activity
Enzyme activity
Gene expression
Gene regulation
Inflammation
Internal Medicine
Liver
Medical Education
Metabolism
MicroRNAs
miRNA
Proteins
Ribonucleic acid
RNA
Signal transduction
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Zusammenfassung:Methods We characterized the acute phase response in human liver by genomewide RNA and miRNA profiling of livers from donors with elevated versus normal levels of the inflammation marker C-reactive protein. In particular miR-130b was shown to be upregulated in inflammation and to downregulate the enzyme activity of several cytochromes...
ISSN:0149-2918
1879-114X
DOI:10.1016/j.clinthera.2017.05.339