Hepatic Disposition Of [11 C] Erlotinib at Micro- and Therapeutic Doses Assessed with Pet Imaging

Hepatic Disposition Of [11 C] Erlotinib at Micro- and Therapeutic Doses Assessed with Pet Imaging

For the therapeutic dose a significant decrease (-39 ± 18%) in the influx rate constant of 11C-erlotinib from blood into hepatocytes was found, whereas the efflux rate constant from hepatocytes into gall bladder and bile duct remained unchanged. Active uptake transport of erlotinib into the liver ma...

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Veröffentlicht in:Clinical therapeutics 2017-08, Vol.39 (8), p.e3-e3
Hauptverfasser: Bauer, M, Matsuda, A, Wulkersdorfer, B, Philippe, C, Nics, L, Klebermass, E.M, Stanek, J, Wadsak, W, Hacker, M, Zeitlinger, M, Langer, O
Format: Artikel
Sprache:eng
Schlagworte:
Imaging
Inhibitor drugs
Internal Medicine
Liver
Medical Education
Metabolites
Plasma
Positron emission
Tomography
Urinary bladder
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Zusammenfassung:For the therapeutic dose a significant decrease (-39 ± 18%) in the influx rate constant of 11C-erlotinib from blood into hepatocytes was found, whereas the efflux rate constant from hepatocytes into gall bladder and bile duct remained unchanged. Active uptake transport of erlotinib into the liver may account for variability...
ISSN:0149-2918
1879-114X
DOI:10.1016/j.clinthera.2017.05.011