The Effects of Candidate SNPS in PKPD Pathway on Antipsychotics-Induced Amenorrhea in Female Schizophrenia Patients

The Effects of Candidate SNPS in PKPD Pathway on Antipsychotics-Induced Amenorrhea in Female Schizophrenia Patients

Background Amenorrhea frequently occurs in female patients taking under antipsychotic drugs (APs).It may affect drug compliance resulting treatment failure. The aim of this study was to explore the genetic effects of candidate single nucleotide polymorphisms (SNPs) in pharmacokinetics and pharmacody...

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Veröffentlicht in:Clinical therapeutics 2017-08, Vol.39 (8), p.e49-e49
Hauptverfasser: Kim, H.S, Moon, J.J, Kim, D.J, Kim, E.Y, Shim, J.C, Shin, J.-G
Format: Artikel
Sprache:eng
Schlagworte:
Amenorrhea
Antipsychotics
Drugs
Genetic effects
Internal Medicine
Medical Education
Mental disorders
Patients
Pharmacodynamics
Pharmacokinetics
Pharmacology
Psychotropic drugs
Schizophrenia
Single-nucleotide polymorphism
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Zusammenfassung:Background Amenorrhea frequently occurs in female patients taking under antipsychotic drugs (APs).It may affect drug compliance resulting treatment failure. The aim of this study was to explore the genetic effects of candidate single nucleotide polymorphisms (SNPs) in pharmacokinetics and pharmacodynamics (PKPD) pathway of APon AP-induced amenorrhea in female schizophrenia patients.
ISSN:0149-2918
1879-114X
DOI:10.1016/j.clinthera.2017.05.151