Safety Profile of Sodium-Glucose Co-Transporter-2 Inhibitors: A Global Analysis of Pharmacovigilance Databases

Safety Profile of Sodium-Glucose Co-Transporter-2 Inhibitors: A Global Analysis of Pharmacovigilance Databases

[...]their safety profile is not fully characterized, especially in terms of rare and unpredictable adverse drug reactions (ADRs), which may escape detection in trials. [...]we conducted a comprehensive analysis of spontaneous reports submitted to the largest pharmacovigilance databases. For canagli...

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Veröffentlicht in:Clinical therapeutics 2017-08, Vol.39 (8), p.e38-e39
Hauptverfasser: Raschi, E, Parisotto, M, Forcesi, E, Marchesini, G, De Ponti, F, Poluzzi, E
Format: Artikel
Sprache:eng
Schlagworte:
Glucose transporter
Internal Medicine
Medical Education
Metabolism
Pharmacology
Pharmacovigilance
Side effects
Sodium
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Zusammenfassung:[...]their safety profile is not fully characterized, especially in terms of rare and unpredictable adverse drug reactions (ADRs), which may escape detection in trials. [...]we conducted a comprehensive analysis of spontaneous reports submitted to the largest pharmacovigilance databases. For canagliflozin (highest number of reports in FAERS=7.389), disproportionality signals emerged for...
ISSN:0149-2918
1879-114X
DOI:10.1016/j.clinthera.2017.05.121