CYP4F2 Genotype Affects Circulating Plasma Vitamin K Concentration In Children on Chronic Warfarin Therapy

CYP4F2 Genotype Affects Circulating Plasma Vitamin K Concentration In Children on Chronic Warfarin Therapy

Recent studies suggest that cytochrome p450 CYP4F2 enzyme is involved in the ω-hydroxylation of vitamin K. Genetic polymorphism in CYP4F2 is thus likely to affect vitamin K systemic availability, which may in turn affect bone development and vascular health in children on long-term anticoagulation t...

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Veröffentlicht in:Clinical therapeutics 2017-08, Vol.39 (8), p.e32-e32
Hauptverfasser: Kampouraki, E, Avery, P, Biss, T, Kamali, F
Format: Artikel
Sprache:eng
Schlagworte:
Berries
Children
Coagulation
Genotype & phenotype
Internal Medicine
Medical Education
Plasma
Therapy
Vitamin E
Vitamin K
Warfarin
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Zusammenfassung:Recent studies suggest that cytochrome p450 CYP4F2 enzyme is involved in the ω-hydroxylation of vitamin K. Genetic polymorphism in CYP4F2 is thus likely to affect vitamin K systemic availability, which may in turn affect bone development and vascular health in children on long-term anticoagulation therapy with warfarin. There was a...
ISSN:0149-2918
1879-114X
DOI:10.1016/j.clinthera.2017.05.100