Cutaneous adverse drug reactions from a teaching hospital in Bengaluru: An observational study to determine the spectrum and outcome

Received: December 06, 2016; Accepted: December 25, 2016 ABSTRACT Background: Cutaneous adverse drug reactions (CADRs) are frequent manifestations of drug reactions that can lead to discontinuation of treatment, impaired quality of life and increased economic burden. Materials and Methods: An observational study conducted from 2012 to 2016 to analyze the CADRs reported from Dermatology Department, of Bangalore Medical College and Research Institute to adverse drug reaction (ADR) Monitoring Center. Maximum CADRs were seen with beta-lactam class of drugs (20%), followed by nonsteroidal anti-inflammatory drugs (17.4%) and antiepileptics (13.5%). Cutaneous Adverse Drug Reactions; Causality; Severity; Preventability INTRODUCTION Adverse drug reaction (ADR) has been defined by the World Health Organization (WHO) as "any response to a drug which is noxious and unintended, and which occurs at doses normally used in man for prophylaxis, diagnosis, or therapy of disease, or for the modification of physiological function."™ It has been estimated to be fourth or sixth leading cause of death among hospitalized patients. [3] Cutaneous ADR (CADR) is any undesirable change in the structure or function of the skin, its appendages or mucous membrane and encompasses all adverse events related to drug eruption, regardless of the etiology. [4] Commonly used drugs implicated in CADRs are penicillins, sulfonamides, anticonvulsants, nonsteroidal anti-inflammatory drugs (NSAIDs), etc. Antimicrobial agents accounted for the highest number of CADRs (37.8%), followed by NSAIDs (17.4%) and antiepileptic drugs (13.5%) (Table 2). Moulya MV, Dinesh R, Nagesh G. Pattern of adverse drug reaction in teaching care hospital in Southern India: A retrospective study...