Liposomes containing monophosphoryl lipid A and QS-21 serve as an effective adjuvant for soluble circumsporozoite protein malaria vaccine FMP013

Highlights • FMP013 in ALFQ adjuvant induced a strong antibody and protective response in mice. • ALFQ was a more potent adjuvant than Montanide ISA 720. • ALFQ enhanced IgG2c, germinal center B-cells and antibody secreting cells. • ALFQ enhanced T-cell responses in a TH 1 biased manner. • FMP013 +...

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Veröffentlicht in:	Vaccine 2017-07, Vol.35 (31), p.3865-3874
Hauptverfasser:	Genito, Christopher J, Beck, Zoltan, Phares, Timothy W, Kalle, Fanta, Limbach, Keith J, Stefaniak, Maureen E, Patterson, Noelle B, Bergmann-Leitner, Elke S, Waters, Norman C, Matyas, Gary R, Alving, Carl R, Dutta, Sheetij
Format:	Artikel
Sprache:	eng
Schlagworte:	Adjuvant Adjuvants Adjuvants, Immunologic - administration & dosage ALFQ Allergy and Immunology Aluminum Aluminum hydroxide Animals Antibodies Antibodies, Protozoan - blood Antigens Army B-Lymphocytes - immunology CD4 antigen CD4-Positive T-Lymphocytes - immunology Cholesterol Circumsporozoite protein Clinical trials Criteria Disease Models, Animal E coli Enzyme-linked immunosorbent assay Enzyme-Linked Immunospot Assay Female FMP013 Hepatitis Immune response Immune system Immunization Immunogenicity Interferon Interferon-gamma - secretion Laboratory animals Lipid A Lipid A - administration & dosage Lipid A - analogs & derivatives Lipids Liposomes Liposomes - administration & dosage Lymphocytes B Lymphocytes T Malaria Malaria Vaccines - administration & dosage Malaria Vaccines - immunology Malaria, Falciparum - prevention & control Medical research Mice Mice, Inbred C57BL Monophosphoryl lipid A Parasites Plasmodium falciparum Proteins Protozoan Proteins - immunology QS-21 Saponins - administration & dosage Series (mathematics) Spleen Toxicology Vaccine Vaccines Vector-borne diseases
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Beschreibung
Zusammenfassung:	Highlights • FMP013 in ALFQ adjuvant induced a strong antibody and protective response in mice. • ALFQ was a more potent adjuvant than Montanide ISA 720. • ALFQ enhanced IgG2c, germinal center B-cells and antibody secreting cells. • ALFQ enhanced T-cell responses in a TH 1 biased manner. • FMP013 + ALFQ is under consideration for a human malaria vaccine trial.
ISSN:	0264-410X 1873-2518
DOI:	10.1016/j.vaccine.2017.05.070