Role of oncogenic EZH2 histone methyltransferase activity in PDAC cellular plasticity

Role of oncogenic EZH2 histone methyltransferase activity in PDAC cellular plasticity

The reprogramming capacity of tumor cells is predominantly controlled at the level of chromatin.PRC2 member EZH2, a histone methyltransferase is one of the epigenetic player that has been linked to tumor cell plasticity. [...]genetic and pharmacological inhibition of EZH2 activity abrogates PDAC cel...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.] 2017-07, Vol.17 (3), p.S41-S41
Hauptverfasser: Patil, Shilpa, Witte, Helena, Neesse, Albrecht, Johnsen, Steven, Ellenrieder, Volker, Hessmann, Elisabeth
Format: Artikel
Sprache:eng
Schlagworte:
Cell proliferation
Chemotherapy
Chromatin
Endocrinology & Metabolism
Gastroenterology and Hepatology
Histone methyltransferase
Plasticity
Tumor cells
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:The reprogramming capacity of tumor cells is predominantly controlled at the level of chromatin.PRC2 member EZH2, a histone methyltransferase is one of the epigenetic player that has been linked to tumor cell plasticity. [...]genetic and pharmacological inhibition of EZH2 activity abrogates PDAC cell proliferation and induces gene signatures that favor...
ISSN:1424-3903
1424-3911
DOI:10.1016/j.pan.2017.05.128