High versus low energy administration in the early phase of acute pancreatitis (GOULASH): Pre-publication protocol of a multicentre randomized double-blind clinical trial

Introduction: Acute pancreatitis (AP) is an inflammatory disease with no specific therapy Mitochondrial injury followed by ATP depletion in both acinar and ductal cells is a recently discovered early event in the pathogenesis. Importantly, preclinical research showed that intracellular ATP delivery restores the physiological function of the cells and protects...