N-acylhydrazones containing thiophene nucleus: a new anticancer class

N-acylhydrazones containing thiophene nucleus: a new anticancer class

In this study, we present a series of N -acylhydrazones containing thiophene nuclei as a new anticancer class. Fifty-seven compounds in this series were evaluated for their activity against four human cancer cell lines. Cytotoxicity (IC 50 ) ranged from 0.82 to 12.90 μM. The compound ( E )- N ′-(2-h...

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Veröffentlicht in:Medicinal chemistry research 2017-08, Vol.26 (8), p.1605-1608
Hauptverfasser: Cardoso, Laura N. F., Nogueira, Thais C. M., Rodrigues, Felipe A. R., Oliveira, Augusto Cesar Aragão, Luciano, Maria Claudia dos Santos, Pessoa, Claudia, de Souza, Marcus V. N.
Format: Artikel
Sprache:eng
Schlagworte:
Berries
Biochemistry
Biomedical and Life Sciences
Biomedicine
Biotechnology
Cancer
Cell Biology
Cytotoxicity
Nuclei
Original Research
Pharmacology/Toxicology
Series (mathematics)
Toxicity
Tumor cell lines
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Zusammenfassung:In this study, we present a series of N -acylhydrazones containing thiophene nuclei as a new anticancer class. Fifty-seven compounds in this series were evaluated for their activity against four human cancer cell lines. Cytotoxicity (IC 50 ) ranged from 0.82 to 12.90 μM. The compound ( E )- N ′-(2-hydroxy-3-methoxybenzylidene)thiophene-2-carbohydrazide displayed good cytotoxic activity in all cell lines (IC 50  = 0.82–5.36 μM) and yielded the best result in this series; therefore, it is an important lead compound in this new class.
ISSN:1054-2523
1554-8120
DOI:10.1007/s00044-017-1832-y