An Overview of 2‐Styrylchromones: Natural Occurrence, Synthesis, Reactivity and Biological Properties

2‐Styrylchromones are a small class of oxygen‐containing heterocycles. Despite their sparse occurrence in nature, several synthetic approaches have been developed in order to synthesize a large variety of derivatives, possessing different substituents in different positions of the main core. They ar...

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Veröffentlicht in:European journal of organic chemistry 2017-06, Vol.2017 (22), p.3115-3133
Hauptverfasser: Santos, Clementina M. M., Silva, Artur M. S.
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Sprache:eng
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Zusammenfassung:2‐Styrylchromones are a small class of oxygen‐containing heterocycles. Despite their sparse occurrence in nature, several synthetic approaches have been developed in order to synthesize a large variety of derivatives, possessing different substituents in different positions of the main core. They are also versatile building blocks in the synthesis of new heterocyclic systems and important intermediates in the search for bioactive compounds. It is our intention in this review to give a general overview on the natural occurrence, synthesis, reactivity and biological properties of 2‐styrylchromones, which were published up until 2016. (E)‐2‐Styrylchromones are a small group of naturally occurring oxygen heterocycles that have been attracting great attention due to their biological activities and also as starting materials in the synthesis of other bioactive oxygen and nitrogen heterocycles. The natural occurrence, reactivity and biological evaluation of these compounds are reviewed, together with methods for their synthesis.
ISSN:1434-193X
1099-0690
DOI:10.1002/ejoc.201700003