Back Cover: Imaging Glycosylation In Vivo by Metabolic Labeling and Magnetic Resonance Imaging (Angew. Chem. Int. Ed. 4/2016)

Cell‐surface glycans were imaged in live mice by magnetic resonance imaging, following metabolic labeling with an azido sugar and subsequent bioorthogonal reaction with a strained cyclooctyne linked to a gadolinium contrast agent. In their Communication on page 1286 ff., A. A. Neves et al. show that...

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Veröffentlicht in:Angewandte Chemie International Edition 2016-01, Vol.55 (4), p.1566-1566
Hauptverfasser: Neves, André A., Wainman, Yéléna A., Wright, Alan, Kettunen, Mikko I., Rodrigues, Tiago B., McGuire, Sarah, Hu, De-En, Bulat, Flaviu, Geninatti Crich, Simonetta, Stöckmann, Henning, Leeper, Finian J., Brindle, Kevin M.
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Sprache:eng
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Zusammenfassung:Cell‐surface glycans were imaged in live mice by magnetic resonance imaging, following metabolic labeling with an azido sugar and subsequent bioorthogonal reaction with a strained cyclooctyne linked to a gadolinium contrast agent. In their Communication on page 1286 ff., A. A. Neves et al. show that significant azido sugar dependent contrast was observed in various tissues two hours after administration of the contrast agent.
ISSN:1433-7851
1521-3773
DOI:10.1002/anie.201511259