A Valuable Upgrade to the Portfolio of Cycloaddition Reactions

A Valuable Upgrade to the Portfolio of Cycloaddition Reactions

Knitting: Recently Antonchick and Manna described a unique annulation that knits together three acetophenones to construct cyclopropanes. The cascade is mediated by organocopper and free radical species, and amounts to the first known [1+1+1] cyclotrimerization. It works well for ketones having elec...

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Veröffentlicht in:Angewandte Chemie International Edition 2016-06, Vol.55 (25), p.7034-7036
1. Verfasser: Walton, John C.
Format: Artikel
Sprache:eng
Schlagworte:
Aromatic compounds
carbocycles
Chemical reactions
copper
Cycloaddition
cyclotrimerization
Ketones
Knitting
Organic chemistry
Organic compounds
radicals
synthetic methods
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Beschreibung
Zusammenfassung:Knitting: Recently Antonchick and Manna described a unique annulation that knits together three acetophenones to construct cyclopropanes. The cascade is mediated by organocopper and free radical species, and amounts to the first known [1+1+1] cyclotrimerization. It works well for ketones having electron‐deficient or electron‐rich substituents in their aryl rings. DTBP=di‐tert‐butylperoxide.
ISSN:1433-7851
1521-3773
DOI:10.1002/anie.201602891