AB0948 Signal Peptide-Cub-Egf Domain-Containing Protein (SCUBE); A Novel Marker in Relation with Anjiogenesis in Rheumatoid Arthritis?

BackgroundRheumatoid Arthritis (RA) is a multifactorial, systemic, progressive, inflammatory disease which is characterized with bone and cartilage destruction. Synovial angiogenesis is important at the etiopathology. Recently with the better understanding of RA pathogenesis, the target specific treatment approaches come up with better results.ObjectivesThe purpose is to study levels of newly identified plasma signal peptide-CUP-EGF domain containing protein (SCUBE) 1and 3 in RA patients. Moreover, to determine whether there exists any correlation between these proteins, other angiogenesis parameters and disease activitiesMethodsThis study covers 106 patients diagnosed with RA associated with 2010 American Collage of Rheumatology (ACR) diagnosis criteria matched with healthy controllers who are equivalent of RA patients in terms of age and gender. All necessary data such as age, gender and body mass index of all participants were recorded. Detailed background information and examination of the patients are recorded and disease activity scores (DAS28) were figured out. The levels of SCUBE 1–3, Vascular Endotedial Growth Factor (VEGF), Matrix metaloproteinaz-9 (MM-9), Interlökin-6 (IL-6), CD40L are evaluated with the method of Enzyme-Linked Immuno-Sorbent Assay (ELISA) in both patients and control groupResultsThis study covers 201 individuals 106 of whom were diagnosed with RA (82 women, 24 men) and 95 of them were healthy controllers (64 women, 31 men). Age, body mass index (BMI) and gender distribution of both groups were very similar to one another. Significant differences were observed between RA patients and healthy controller groups in terms of SCUBE 1 (respectively1.28±1.41ng/mL, 0.94±0.67ng/mL p=0.002) and CD40L MMP-9 levels (p