SAT0334 Nationwide Trends in Hospitalization and in-Hospital Mortality Associated with Anca-Associated Vasculitis (AAV)

BackgroundANCA-associated vasculitis (AAV) is associated with severe end-organ damage (e.g., renal failure) and treatment-related complications (e.g., severe infection) which often lead to hospitalization. However, no data on recent hospitalization trends and associated mortality are available1.ObjectivesWe evaluated recent trends in nationwide hospitalization, cost, and in-hospital mortality among patients with AAV.MethodsWe used the National Inpatient Survey (NIS) which is the largest all-payer inpatient database in the US. We studied all hospitalizations with a discharge diagnosis of AAV (ICD 9: 446.4) between 1993 and 2011. We investigated trends in hospitalization, cost, and mortality by comparing AAV to overall inpatient hospitalization trends. Analyses were performed using hospital-level sampling weights provided by the NIS to obtain US national estimates.ResultsFrom 1993 to 2011, the rate of hospitalization for AAV increased from 1.9/100,000 persons to 4.5/100,000 persons (P-for-trend