AB1034 The Epidemiology of The Rheumatic Manifestations Associated with Inflammatory Bowel Disease: The Preliminary Data from A Hospital-Based Cohort Study in Istanbul

BackgroundRheumatic manifestations are the most common frequent extra-intestinal manifestations (EIM) of inflammatory bowel disease (IBD), which includes Crohn's disease (CD) and ulcerative colitis (UC), and affected 6–46% of patients1. Despite the common manifestations, data on the various ethnic populations are limited so far. Therefore, the cohort study seems a more useful tool to learn more about epidemiology and possible risk factors in the different geographical and racial groups2.ObjectivesWe conducted this survey to estimate the prevalences of some rheumatic manifestations associated with IBD and to study epidemiological factors of IBD in Istanbul, Turkey.MethodsThe patients were enrolled from the Gastroenterological Out-patient Clinics at two Hospitals. The diagnosis was made by gastroenterologists using endoscopy and histological studies. All patients with established diagnosis of CD and UC were evaluated byr heumatolgogists for EIM. Inflammatory back pain (IBP) was defined according to Calin's criteria. The modified New York criteria were used to define ankylosing spondylitis (AS) and the European Spondyloarthropathy Study Group criteria for spondyloarthropathy (SpA).ResultsA total of 223 patients diagnosed as IBD.115 ulcerative colltis (UC) and 108 Crohn'sdisease (CD).We estmated the prevalence of IBP as 21%; AS: 2.7%; sacroiliitis (SA): 5.4%; psoriasis: 1.3%; psoriatic arthritis (PsA): 0.9%; pustulosis: 0.9%; uveitis: 1.8%; polyarticular arthritis: 6%; oligoarticular arthritis: 9%; arthralgia: 27%; erythema nodosum (EN): 2.2%; recurrent oral aphthous (ROU): 18.4% (Table 1).Table 1.Demographic and clinical features of patients with IBDTotal, n (%)UCCDIBD no.223115108Age41.8±12.643.5±12.639.8±11.9Arthralgia60 (27%)2733Polyarticular arthritis14 (6%)68Oligoarticular arthritis20 (9%)1010IBP46 (21%)2719Heel pain16 (7%)115AS6 (2.7%)51SA12 (5.4%)66SpA4 (1.8%)22Psoriasis3 (1.3%)21PsA2 (0.9%)02Uveitis4 (1.8%)13E. nodosum5 (2.2%)32Pustulosis2 (0.9%)11ROU41 (18.4%)1922MN: manifestations, IBD: inflammatory bowel disease, AS: ankylosing spondylitis, IBP: inflammatory back pain, SpA: spondyloarthropathy, PsA: psoriatic arthritis, UC: ulcerative colitis, CD: Crohn's disease, ROU: recurrent oral aphthous, SA: sacroiliitis.ConclusionsWe concluded that AS occurs more frequently in IBD, and more often than the prevalence of AS found in the general population. There is a high prevalence of IBP in IBD. The prevalence of ROU significantly higher than in the health p