FRI0462 Gender Differences in The Disease Expression and Articular Manifestations among Patients with Psoriatic Arthritis. Data from The Bepas Cohort

BackgroundPsoriatic arthritis (PsA) is a common form of chronic arthritis strongly associated with the skin disease psoriasis. The gender distribution is considered equal but it is suggested that their might be gender related differences in disease expression, disease activity and outcome. The BEPAS cohort (Belgian Epidemiological Psoriatic Arthritis Study) is a large prospective multicenter real life cohort set up in 17 Belgian large academic and non academic rheumatology practices that offers a unique opportunity to study the disease patterns with their respective articular and skin involvement in this patient groupObjectives(1) To assess gender-related differences in disease patterns and articular manifestations of psoriatic arthritisMethodsA cross-sectional analysis at the inclusion visit was performed among the male and female patients included in the BEPAS cohort. They were evaluated for the demographics, the disease patterns at diagnosis and the presence of clinical articular and extra–articular manifestations at inclusion. Gender differences were evaluated by one way ANOVA or Chi –square testing.Results461 patients including 263 male patients and 198 female patients with mean age: 52.79 years (±12.29) were recruited in the 17 centers from December 2012 to July 2014.There was no gender difference in rheumatoid factor, anti–CCP and extra-articular manifestations such as uveitis and inflammatory bowel diseaseMale (263)Female (198)PmeanSDmeanSDAge of onset PsA45.02313.244.15150.507Age of onset PsO35.3814.0633.6917.950.286PsA disease duration at inclusion8.458.748.799.990.701HLA B27 (n=112) (%)9.89.8>0.5BMI27.854.5226.945.430.06Psoriasis type 1165 (62.7)122 (61.6)>0.5Numbers of DMARDS1.620.951.591.0170.735Actual use of anti TNF130 (50.2)74 (37.8)0.008Oligo at diagnosis (%)93 (20.2)61 (13.2)0.305Poly at diagnosis (%)134 (29.1)78 (16.9)0.014Clinical articular and skin manifestations at inclusion IBP (Rudwaleit criteria ≥2/4)76 (28.9)81 (40.9)0.007 TJ783.716.754.557.780.215 SJ762.35.191.883.310.318 Number of enthesitis0.732.131.634.080.004 Number of dactylitis0.351.20.20.660.114 BSA4.8711.123.036.660.074 Nail involvement85 (32.3)37 (18.9)0001ConclusionsThe disease patterns and clinical manifestations differ in several aspects between male and female PsA. They have a different clinical articular presentation at diagnosis: male patients have more polyarticular disease while female patients have more entheseal disease. Skin involvement is comparable except fo