SAT0129 Vitamin D Status and Its Association with Disease Activity, Severity and Physical Disability in Rheumatoid Arthritis Patients
BackgroundVitamin D has immunomodulatory effects in a wide range of human autoimmune diseases; including Rheumatoid Arthritis (RA). Vitamin D deficiency is common in RA.ObjectivesThe objective of this study was to evaluate vitamin D status in RA patients and assess the relationship between vitamin D...
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| Veröffentlicht in: | Annals of the rheumatic diseases 2016-06, Vol.75 (Suppl 2), p.711 |
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| creator | Akkar, O. Ichchou, L. |
| description | BackgroundVitamin D has immunomodulatory effects in a wide range of human autoimmune diseases; including Rheumatoid Arthritis (RA). Vitamin D deficiency is common in RA.ObjectivesThe objective of this study was to evaluate vitamin D status in RA patients and assess the relationship between vitamin D levels, disease activity, severity and physical disability.MethodsWe included in this cross-sectional study patients with RA according to ACR/EULAR classification criteria, followed up at the Department of Rheumatology. Demographic characteristics and disease specific variables were collected. Disease activity was assessed by the Disease Activity Score (DAS 28). Functional disability was evaluated by the Health Assessment Questionnaire (HAQ). Joint destruction was assessed by the van der Heijde-modified Sharp Score. Serum concentrations of 25(OH) Vitamin D were measured. According to the GRIO recommendations, 25(OH)D insufficiency was defined as 25(OH)D ranging from 10 to 30 ng/mL, and deficiency as 25(OH)D |
| doi_str_mv | 10.1136/annrheumdis-2016-eular.5083 |
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Vitamin D deficiency is common in RA.ObjectivesThe objective of this study was to evaluate vitamin D status in RA patients and assess the relationship between vitamin D levels, disease activity, severity and physical disability.MethodsWe included in this cross-sectional study patients with RA according to ACR/EULAR classification criteria, followed up at the Department of Rheumatology. Demographic characteristics and disease specific variables were collected. Disease activity was assessed by the Disease Activity Score (DAS 28). Functional disability was evaluated by the Health Assessment Questionnaire (HAQ). Joint destruction was assessed by the van der Heijde-modified Sharp Score. Serum concentrations of 25(OH) Vitamin D were measured. According to the GRIO recommendations, 25(OH)D insufficiency was defined as 25(OH)D ranging from 10 to 30 ng/mL, and deficiency as 25(OH)D <10 ng/mL. Data analysis was carried out using the SPSS 20 Software. p<0.05 was considered statistically significant.ResultsSeventy-tree patients with a mean±SD age of 52.04 ± 12.26 years were enrolled. Sixty-nine percent were females. Mean±SD duration of symptoms was 11.61 ± 8.43 years. The prevalence of 25(OH)D insufficiency and deficiency was 69.9% and 17.8% successively. The univariate analysis showed a significant correlation between 25(OH)D serum concentration, number of swollen joints (p=0.024) and disease activity (p=0.012). In multivariate analysis adjusted for age, Sharp score, and C-Reactive Protein, there was a significant correlation between 25(OH)D serum concentration and disease activity (p=0.048).ConclusionsVitamin D deficiency is highly prevalent and is associated with higher disease activity in our RA patients. Therefore, Vitamin D measurement and possibly vitamin D supplementation should be considered in the management of RA patients.Disclosure of InterestNone declared</description><identifier>ISSN: 0003-4967</identifier><identifier>EISSN: 1468-2060</identifier><identifier>DOI: 10.1136/annrheumdis-2016-eular.5083</identifier><identifier>CODEN: ARDIAO</identifier><language>eng</language><publisher>Kidlington: Elsevier Limited</publisher><ispartof>Annals of the rheumatic diseases, 2016-06, Vol.75 (Suppl 2), p.711</ispartof><rights>2016, Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions</rights><rights>Copyright: 2016 (c) 2016, Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-b1857-e615765c46ac34c0ed2d8b87ae1e614446a099ea265cf730077c0a49f7c8d19e3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttp://ard.bmj.com/content/75/Suppl_2/711.3.full.pdf$$EPDF$$P50$$Gbmj$$H</linktopdf><linktohtml>$$Uhttp://ard.bmj.com/content/75/Suppl_2/711.3.full$$EHTML$$P50$$Gbmj$$H</linktohtml><link.rule.ids>114,115,314,776,780,3182,23551,27903,27904,77347,77378</link.rule.ids></links><search><creatorcontrib>Akkar, O.</creatorcontrib><creatorcontrib>Ichchou, L.</creatorcontrib><title>SAT0129 Vitamin D Status and Its Association with Disease Activity, Severity and Physical Disability in Rheumatoid Arthritis Patients</title><title>Annals of the rheumatic diseases</title><description>BackgroundVitamin D has immunomodulatory effects in a wide range of human autoimmune diseases; including Rheumatoid Arthritis (RA). Vitamin D deficiency is common in RA.ObjectivesThe objective of this study was to evaluate vitamin D status in RA patients and assess the relationship between vitamin D levels, disease activity, severity and physical disability.MethodsWe included in this cross-sectional study patients with RA according to ACR/EULAR classification criteria, followed up at the Department of Rheumatology. Demographic characteristics and disease specific variables were collected. Disease activity was assessed by the Disease Activity Score (DAS 28). Functional disability was evaluated by the Health Assessment Questionnaire (HAQ). Joint destruction was assessed by the van der Heijde-modified Sharp Score. Serum concentrations of 25(OH) Vitamin D were measured. According to the GRIO recommendations, 25(OH)D insufficiency was defined as 25(OH)D ranging from 10 to 30 ng/mL, and deficiency as 25(OH)D <10 ng/mL. Data analysis was carried out using the SPSS 20 Software. p<0.05 was considered statistically significant.ResultsSeventy-tree patients with a mean±SD age of 52.04 ± 12.26 years were enrolled. Sixty-nine percent were females. Mean±SD duration of symptoms was 11.61 ± 8.43 years. The prevalence of 25(OH)D insufficiency and deficiency was 69.9% and 17.8% successively. The univariate analysis showed a significant correlation between 25(OH)D serum concentration, number of swollen joints (p=0.024) and disease activity (p=0.012). In multivariate analysis adjusted for age, Sharp score, and C-Reactive Protein, there was a significant correlation between 25(OH)D serum concentration and disease activity (p=0.048).ConclusionsVitamin D deficiency is highly prevalent and is associated with higher disease activity in our RA patients. Therefore, Vitamin D measurement and possibly vitamin D supplementation should be considered in the management of RA patients.Disclosure of InterestNone declared</description><issn>0003-4967</issn><issn>1468-2060</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNqVkM1OAjEUhRujiYi-QxO2Dt4yM20nribgDwmJRNBt0-mUUAIz2HYw7NwY39MnsQMu3Lrq7bnnnDYfQj0CfUJieiOryi51symNiwZAaKSbtbT9FHh8gjokoTzIFE5RBwDiKMkoO0cXzq3CFTjhHfQ1y-dABtn3x-er8XJjKjzCMy9947CsSjz2DufO1cpIb-oKvxu_xCPjtHQa58qbnfH7azzTO23DdMhMl3tnlFy3PlmYdauH3uf2p9LXpsS59ctgNw5PQ62uvLtEZwu5dvrq9-yil_u7-fAxmjw9jIf5JCoIT1mkKUkZTVVCpYoTBboclLzgTGoSVkkSdMgyLQfBs2AxAGMKZJItmOIlyXTcRb1j79bWb412XqzqxlbhSUEyIJxCyllw3R5dytbOWb0QW2s20u4FAdGSF3_Ii5a8OJAXLfmQpsd0sVn9K_gDgEuRQg</recordid><startdate>201606</startdate><enddate>201606</enddate><creator>Akkar, O.</creator><creator>Ichchou, L.</creator><general>Elsevier Limited</general><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88I</scope><scope>8AF</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>BTHHO</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9-</scope><scope>K9.</scope><scope>LK8</scope><scope>M0R</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>M7P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope></search><sort><creationdate>201606</creationdate><title>SAT0129 Vitamin D Status and Its Association with Disease Activity, Severity and Physical Disability in Rheumatoid Arthritis Patients</title><author>Akkar, O. ; Ichchou, L.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-b1857-e615765c46ac34c0ed2d8b87ae1e614446a099ea265cf730077c0a49f7c8d19e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Akkar, O.</creatorcontrib><creatorcontrib>Ichchou, L.</creatorcontrib><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>ProQuest Health and Medical</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>STEM Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection (ProQuest)</collection><collection>BMJ Journals</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>Consumer Health Database (Alumni Edition)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Consumer Health Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Science Database (ProQuest)</collection><collection>ProQuest Biological Science Journals</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><jtitle>Annals of the rheumatic diseases</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Akkar, O.</au><au>Ichchou, L.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>SAT0129 Vitamin D Status and Its Association with Disease Activity, Severity and Physical Disability in Rheumatoid Arthritis Patients</atitle><jtitle>Annals of the rheumatic diseases</jtitle><date>2016-06</date><risdate>2016</risdate><volume>75</volume><issue>Suppl 2</issue><spage>711</spage><pages>711-</pages><issn>0003-4967</issn><eissn>1468-2060</eissn><coden>ARDIAO</coden><abstract>BackgroundVitamin D has immunomodulatory effects in a wide range of human autoimmune diseases; including Rheumatoid Arthritis (RA). Vitamin D deficiency is common in RA.ObjectivesThe objective of this study was to evaluate vitamin D status in RA patients and assess the relationship between vitamin D levels, disease activity, severity and physical disability.MethodsWe included in this cross-sectional study patients with RA according to ACR/EULAR classification criteria, followed up at the Department of Rheumatology. Demographic characteristics and disease specific variables were collected. Disease activity was assessed by the Disease Activity Score (DAS 28). Functional disability was evaluated by the Health Assessment Questionnaire (HAQ). Joint destruction was assessed by the van der Heijde-modified Sharp Score. Serum concentrations of 25(OH) Vitamin D were measured. According to the GRIO recommendations, 25(OH)D insufficiency was defined as 25(OH)D ranging from 10 to 30 ng/mL, and deficiency as 25(OH)D <10 ng/mL. Data analysis was carried out using the SPSS 20 Software. p<0.05 was considered statistically significant.ResultsSeventy-tree patients with a mean±SD age of 52.04 ± 12.26 years were enrolled. Sixty-nine percent were females. Mean±SD duration of symptoms was 11.61 ± 8.43 years. The prevalence of 25(OH)D insufficiency and deficiency was 69.9% and 17.8% successively. The univariate analysis showed a significant correlation between 25(OH)D serum concentration, number of swollen joints (p=0.024) and disease activity (p=0.012). In multivariate analysis adjusted for age, Sharp score, and C-Reactive Protein, there was a significant correlation between 25(OH)D serum concentration and disease activity (p=0.048).ConclusionsVitamin D deficiency is highly prevalent and is associated with higher disease activity in our RA patients. Therefore, Vitamin D measurement and possibly vitamin D supplementation should be considered in the management of RA patients.Disclosure of InterestNone declared</abstract><cop>Kidlington</cop><pub>Elsevier Limited</pub><doi>10.1136/annrheumdis-2016-eular.5083</doi></addata></record> |
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| title | SAT0129 Vitamin D Status and Its Association with Disease Activity, Severity and Physical Disability in Rheumatoid Arthritis Patients |
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