FRI0619-HPR Investigating The Effects of A Multidimensional Exercise Program on Symptoms and Antiinflammatory Status in Oa Patients of The Knee

BackgroundEffects of exercise on pain, physical function, daily living activities and cytokines have been investigated in osteoarthritis (OA) patients (1). However there is no reported multidimensional approach including all these parameters at once in OA patients. On the other hand, the cognitive exercise therapy approach (BETY: Bilişsel Egzersiz Terapi Yaklaşımı) was used as a multidimensional exercise model including effects of improvements on symptoms and anti-inflammatory status in ankylosing spondylitis patients (2).ObjectivesThe purpose of this study is to investigate the effects of a multidimensional (BETY) exercise program on symptoms and anti-inflammatory status in OA patients of the knee.MethodsForty patients with knee osteoarthritis defined as Kellgren-Lawrence (K-L) grade1 and 2, were included in this study, and divided randomly into two groups (BETY group and control). Health Assessment Questionnaire (HAQ), The Western Ontario and McMaster Universities Arthritis Index (WOMAC) was used for functional evaluation and IL-6 were analyzed for anti-inflammatory status in both groups. Control group did not get any exercise intervention. However, BETY group were participated to exercise sessions 3 times a week for 10 weeks. All measurements were repeated after 10 weeks in both groups.ResultsWOMAC pain, physical function and WOMAC total score values were decreased significantly (p0.05). Although any significant change in IL-6 in both groups were not observed, IL-6 decreased in BETY group. Moreover, TNF-a showed significant increase in control group (p0.05). There was no difference between two groups after 10 weeks (p>0.05).Table.1.Comparison of the all scoresBETY group (n=19)Control group (n=21)P intergroupsX ± SDpX ± SDpBeforeAfterBeforeAfterWOMAC pain3.94±2.203.44±2.000.0193.09±1.492.87±1.780.5310.373WOMAC function4.30±1.913.24±1.810.0133.40±1.563.01±2.370.0450.610WOMAC stiffness0.46±0.220.41±0.230.2230.35±0.240.34±0.230.8320.419WOMAC total8.71±4.167.09±3.720.0157.00±3.146.23±4.140.0990.452HAQ11.88±8.509.29±9.060.2248.38±6.296.42±5.450.1710.490IL-65.21±6.122.96±1.770.0532.68±0.762.45±1.140.1950.524TNF-a4.45±2.004.65±2.470.7533.44±2.104.27±2.090.0470.641ConclusionsThis study is an original study in terms of analyzing exerci