AB0443 Relation Between Accumulative Damage and Disability Recogniced by The INSS in Systemic Lupus Erythematosus Patients

BackgroundSystemic Lupus Erythematosus (SLE) in a multisystemic and autoimmune disease that specially affects young women during the second and third decade, and is able to injure different organs and or systems, being the most common one affected the musculoskeletal system. Events attributed to SLE itself and other related to the disease may impact negatively in the quality of life, unemployment, disability and mortality. Recent data show that 3.8% of SLE patients have comorbidities and 59.2% of them were receiving a disability pension. In Spain, the evaluation of disability and the assignation of the mentioned pension is given by the National Social Security Institute of Spain (INSS: Instituto Nacional de la Seguridad Social).ObjectivesTo assess the relationship between cumulative damage regarding to the affected organ and the percentage of disability recognized by the INSS in SLE patients in Spain.MethodsCross-sectional prospective study of SLE patients according to the SLICC-2012 criteria, from the Rheumatology Service of Arnau de Vilanova Hospital and La Fe Hospital. We collected clinical and demographic data through personal interview and the SLIC-ACR questionnaire.ResultsA total of 140 patients were evaluated; of them, 95% were women with 33.39±13.63 year-old average at the diagnosis time with a 10.05±1.42 year-evolution of SLE. Clinical characteristics of each group are described in the table.Without disabilityWith disabilityN98.0042.00Disability (%)053.14±23.7SLICC0.75±0.981.8±1.10Age at SLE diagnosis34.6±14.830.7±10.4SLE evolution (years)13.9±10.720.7±8.10Nervous system damage (%)12.2428.57Musculoskeletal damage (%)88.7890.48Mucocutaneus damage (%)72.4576.19Serositis (%)7.1414.29Cardiovascular damage (%)13.2719.05Cytopenia (%)42.8647.62Renal damage (%)13.2719.05Raynaud's (%)29.5947.62Antiphospholipid synd. (%)7.1411.90Sjögren synd. (%)16.3323.81Vasculitis (%)1.024.76ConclusionsWe observed a positive correlation between percentage of recognized disability and the SLICC-ACR index score. Musculoskeletal system is, in general, the most affected one, without differences between both groups; but we found a higher proportion of damage in nervous system, renal and vasculitis in patients with a recognized disability.Disclosure of InterestNone declared