FRI0444 Early Detection of Psoriatic Arthritis: A Multi-Omic Approach To Developing A New Blood Test

BackgroundPsoriatic Arthritis (PsA) is a form of seronegative inflammatory arthritis (IA) frequently associated with psoriasis. Similar to other forms of IA, it is a complex heterogeneous disease. While PsA can be characterised by distinct clinical manifestations, at early onset, it often resembles other disease types - especially rheumatoid arthritis (RA). During the treatment and management of the disease important clinical decisions are made and these have a significant impact on patient outcomes. Making an accurate and early diagnosis is particularly important to ensuring that individual patients receive effective and safe medication. Thus, it is widely acknowledged by physicians and patients alike that a new test is needed to facilitate the early and specific diagnosis of PsA [1].ObjectivesTo (i) identify candidate biomarkers with the potential to segregate patients with PsA from those with RA (ii) explore the value of combining different omic discovery platforms.MethodsSerum samples were obtained from a cohort of 64 patients (32 PsA and 32 RA) defined as early onset (