AB0459 Tuberculosis among Systemic Lupus Erythematosus Mexican Mestizo Patients

BackgroundTuberculosis (TB) represents a major global health problem. TB has a higher incidence among patients with autoimmune rheumatic diseases than in the general population. The incidence and severity of TB in patients with systemic lupus erythematosus (SLE) varies greatly among different series (2.5–13.8%).ObjectivesTo investigate the frequency and characteristics of TB in Mexican mestizo patients with SLE.MethodsWe reviewed the charts of 123 patients with SLE in our lupus clinic. Patients who developed TB after the diagnosis of SLE were identified. Data of all SLE patients followed up in our clinic were retrospectively analyzed. Clinical and demographic characteristics and treatment before diagnosis of TB were recorded.ResultsA total of 123 SLE patients were analyzed, 89.43% (n=110) woman. Seven cases (5.69%) of TB infection developed after the diagnosis of SLE. Pulmonary TB was reported in 3 patients (2.44%). Extra-pulmonary TB infecction was reported in 3 (2.44%) patients (one case of tuberculous pleurisy, one case of meningeal TB, and 1 case of cutaneous TB). Also, we found 1 SLE patient (0.81%) with latent TB infection. All patients had good response to treatment. No one received biologic therapy at the time of the diagnosis of TB infection. We did not found any case of disseminated infection or mortality related to TB infection.ConclusionsThese results suggest that in a country with high TB burden, TB screening and treatment of latent TB would be useful since the diagnosis of SLE is made.ReferencesErdozain, J. G., Ruiz-Irastorza, G., Egurbide, M. V., Martinez-Berriotxoa, A., & Aguirre, C. (2006). High risk of tuberculosis in systemic lupus erythematosus? Lupus, 15(4), 232–235.Disclosure of InterestNone declared