OP0218 Evaluation of The Acr and Slicc Classification Criteria in Juvenile Systemic Lupus Erythematosus: A Longitudinal Analysis

BackgroundJuvenile-onset systemic lupus erythematosus (JSLE) is a severe multi-system inflammatory disease with very varied presentation and disease course. Diverse clinical manifestations means classification of JSLE can prove challenging. The Systemic Lupus International Collaborating Clinics (SLICC) group proposed revised classification criteria for systemic lupus erythematosus (SLICC-2012 criteria)1.ObjectivesThis study aimed to compare the SLICC-2012 criteria with the widely used American College of Rheumatology classification criteria (ACR-1997 criteria)2.3 in a national cohort of JSLE patients and evaluate how classification criteria that individual patients meet evolved over time.MethodsData from patients in the UK JSLE Cohort Study with a senior clinician diagnosis of probable, evolving or definite JSLE was reviewed. Patients were classified using both criteria within one year of diagnosis and at latest follow-up (following a minimum twelve month follow-up period). Sensitivity of each classification criteria was compared using McNemar's test.Results226 patients were included. The SLICC-2012 was more sensitive than ACR-1997 at diagnosis (92.9% vs 84.1% p