AB0985 The Influence of Etanercept on Inflammation Markers and Lipid Profile in Patients with Juvenile Idiopathic Arthritis

BackgroundChronic inflammatory diseases such as rheumatoid arthritis, systemic lupus erythematosus had been proven to have a higher risk of atherosclerosis and premature coronary artery disease. On the other hand, the role of inflammation on dyslipidemia in patients with juvenile idiopathic arthritis (JIA), is not yet well established.ObjectivesWe have investigated whether etanercept (tumor necrosis factor-α receptor blocking agent) has the influence on inflammation markers and lipid profile in patients with JIA, after 1 year of treatment.MethodsA total of 50 patients with active polyarticular JIA and 31 healthy children were enrolled in the study. JIA patients donated paired blood samples prior to and 12 months after etanercept therapy. Inflammation markers (erythrocite sedimentation rate (ESR), white blood cells count (WBC) and C-reactive protein (CRP) level), as well as serum cholesterol, triacylglycerol, LDL-C and HDL-C levels were determined using standard biochemical analysis.ResultsESR, WBC count and CRP levels were significanly higher in JIA patients before treatment in comparison to control (p=0.001, p=0.048, p