AB0444 Evaluation of Cumulative Damage in Systemic Lupus Erythematosus Patients as A New Cardiovascular Risk Factor

BackgroundThe first cause of mortality in patients with Systemic Lupus Erythematosus (SLE) is cardiovascular disease (CVD). Accelerated atherosclerosis that occurs in SLE is considered one of the fundamental mechanisms of the increase of cardiovascular mortality in this group of patients. Among the factors that contribute to the accelerated atherosclerosis process, we include the classical CVD risk factors, as well as the inflammatory and specific SLE factors.ObjectivesTo assess the CVR in SLE patients and the possibility of modifying it based on the accumulative damage and the disease activity.MethodsCross-sectional prospective study of SLE patients according to the SLICC-2012 criteria, from the Rheumatology Service of Arnau de Vilanova Hospital and La Fe Hospital. All patients had a complete blood-test with autoimmunity markers, and clinical, biometrics and treatment data were collected. Biostatistical analysis was performed with the R software version 3.2.3.Results140 patients were evaluated; (95% women) with 33.39±13.63 year-old average at the diagnosis time with a 10.05±11.42 year-evolution of SLE. 15% of patients had had some kind of CVD; in them, we observe an increase of the classical cardiovascular risk factors comparing to the group who hadn't had any CVD manifestation.We found a statistically significant association between high scores in the SLICC-ACR index (P