SAT0489 Disease Activity and Health Status in a Cohort of Young Adults with JIA

BackgroundJuvenile Idiopathic Arthritis (JIA) is the most prevalent chronic rheumatic disease in childhood. Disease activity can persist for many years, even through adulthood.ObjectivesTo evaluate disease activity and health status in a cohort of young adults with JIA.MethodsIn order to identify patients with persistent active disease or in Clinical Remission off medication (CR) according to Wallace criteria all young people (over 18 year old), followed in our Transitional Care Clinic, were assessed by clinical examination [including registration of number of joints with swelling, tenderness and limited range of motion (LROM), number of active joints] and laboratory parameters. Physician's global assessment of disease activity measured on a 10 cm VAS, Quality of life according to the Medical Outcome Study 36-item Short Form Health Survey (SF-36), physical disability and discomfort by the Health Assessment Questionnaire (HAQ) were also recorded.Results335 consecutive JIA pts (F 237) were evaluated: 39 (11.6%) systemic arthritis, 117 (34.9%) persistent oligoarticular, 48 (14.3%) extended oligoarticular, 80 (23.8%) polyarticular JIA (21 were RF positive), 37 ERA (11%), 14 psoriasic JIA (4.1%). Median age at disease onset was 7.0 yrs (mean 7.8, range 0.1-16.0). Median disease duration was 21.9 yrs (mean 22.7, range 7-51). 237/335 pts were on antirheumatic medication: 134 with biological therapy (BT), 167 with one or more DMARDs and 125 with NSAIDs. Out of the 134 treated with BT 90 were also treated with one or more DMARDs. 98 pts were off medication: 66 of them (67.3%) were inactive and 73 had physician's VAS