AB0748 Treatment Satisfaction with Tumour Necrosis Factor-Alpha Inhibitors (ANTI-TNF) in Ankylosing Spondylitis

BackgroundAnti-TNF treatments are currently the only therapeutic option when conventional treatment fails in ankylosing spondylitis (AS) patients.ObjectivesIn this study we aimed to determine the variables associated with treatment satisfaction and change in quality of life (QOL) with anti-TNF treatment in AS.MethodsPatients with AS were recruited from two tertiary rheumatology centers in Turkey (Uludag and Trakya universities). The patients who met fulfilling the 1984 modified New York classification criteria were enrolled in a cross-sectional manner. Treatment satisfaction and QOL were assessed using visual analogue scales in which 0 indicated the worst and 10 indicated the best outcomes. Bath Ankylosing Spondylitis Disease Activity Index (BASDAI), Bath Ankylosing Spondylitis Functional Index (BASFI), hospital anxiety and depression scale (HADS), somatic symptom checklist, and Self-Administered Leeds Assessment of Neuropathic Symptoms and Signs (SLANSS) were evaluated. Univariate correlation and multivariate regression analyses were applied to determine the variables associated with treatment satisfaction and QOL.ResultsA total of the 277 AS patients (202M, 75F, the mean age was, 39.9±11.3 year and the mean disease duration was15.9±9.2 year) were included in the study. HADS-D, LANSS, SOMATIC SS, BASDAI, BASFI were negatively correlated with both treatment satisfaction and QOL. Also, HADS-A was negatively correlated with treatment satisfaction but not in QOL. Multivariate logistic regression analysis revealed that HADS-A, HADS-D, LANSS, SOMATIC SS, BASDAI, BASFI were independent risk factors associated with treatment satisfaction (Table 1) whereas the HADS-D, SOMATIC SS and BASDAI were independent risk factors associated with QOL.ConclusionsThese findings suggest that psychological status should be examined along with disease activity while assessing patients with AS.ReferencesKilic G, Kilic E, Ozgocmen SMedicine (Baltimore). 2014 Dec;93(29)Giacomelli R, Gorla R, Trotta F, Tirri R, Grassi W, Bazzichi L, Galeazzi M, Matucci-Cerinic M, Scarpa R, Cantini F, Gerli R, Lapadula G, Sinigaglia L, Ferraccioli G, Olivieri I, Ruscitti P, Sarzi-Puttini P.Disclosure of InterestNone declared