AB1006 Serum Vitamin D Levels During Activation and Remission Periods of Patients with Juvenile Idiopathic Arthritis and Familial Mediterranean Fever

BackgroundJuvenile idiopathic arthritis (JIA) and familial Mediterranean fever (FMF) are the most common chronic inflammatory rheumatic disorder in children and is a significant cause of both short- and long-term disabilities. The fact that vitamin D inactivates Th1 and Th17, both of which are thought to have a role in JIA pathophysiology, supports the claim that there may be a relationship between vitamin D deficiency and JIA. However, data are limited regarding the association between disease activity and serum 25(OH)D levels in children with JIA. In the few studies serum 25(OH)D levels were found to correlate inversely with disease activity in patients with FMF.ObjectivesThe aims of this study were to determine the frequency of vitamin D deficiency and/or insufficiency of children with JIA and FMF and to assess the relationship between vitamin D and disease activity for JIA and FMF.Methods64 patients with JIA, 36 patient with FMF and 100 healthy children were included in this prospective cross-sectional study. The children with JIA were diagnosed according to classification criteria of the International League of Associations for Rheumatology (ILAR), and children with FMF according to the criteria set by Livneh. Serum 25-hydroxyvitamin D levels [25(OH)D] of children with JIA and FMF during activation and remission periods were measured using chemiluminescence immunoassay (CLIA). The serum levels of