SAT0299 Tools to Identify Low Bone Mineral Density in HIV-Infected Men

BackgroundHIV-infected patients are at high risk of fragility fractures as they experience early decline in muscle mass and in bone mineral density (BMD), which is the most important independent risk factor for bone fragility. Several tools have been developed to identify subgroups at highest risk of low BMD. Most of them include well established determinants of BMD, as age and weight, but in the last years the potential independent role of lean mass has been speculated. Middle upper arm circumference (MUAC) highly correlates to skeletal muscle mass in HIV-infected males and EPIPOST [1], a tool developed to identify men in the general population with low BMD, supports that lean mass, indirectly measured by MUAC, is the best predictor of low BMD. We hypothesize that as HIV-infected patients experience sarcopenia, EPIPOST may be more suitable to identify low BMD in this population.ObjectivesTo evaluate the discriminatory capacity of Osteoporosis Screening Tool (OST; based on weight and age) and EPISPOT (based on MUAC) to identify low bone mineral density HIV-infected men.MethodsCross-sectional evaluation of 118 HIV-infected Caucasian men, on combination antiretroviral therapy, followed in the Endocrinology outpatient clinic of São João Hospital Centre. Data on gender, age, weight, height, MUAC and femoral neck BMD (LUNAR EXPERT-XL) was collected. T-scores were calculated as recommended by the World Health Organization (the number of standard deviations (SD) by which an individual measurement differs from the mean value for healthy adult female population aged 30 years; the reference population were obtained from the NHANES III study). Patients with T-score -2), EPIPOST had a SE of 100%, a SP of 3.6%, a PPV of 7.8% and a NPV of 100%.ConclusionsWe conclude that, even though both tools show reason