AB0576 Factors Related to Damage Accrual in a Roumanian Systemic Lupus Erythematosus Cohort

BackgroundSystemic lupus erythematosus (SLE) is an idiopathic autoimmune disease associated with significant co-morbidity, affecting both quality of life, but also life expectancy. In most of the cases, disease course and treatment have an important contribution to accumulation of damage. This is way, for patients with SLE it is important to obtain control of disease activity, but also to prevent irreversible organ damage.ObjectivesWe performed a prospective, observational study aiming to evaluate possible factors related to damage accrual in a roumanian SLE cohort.MethodsThis study included 65 patients diagnosed with SLE according to ACR 1997 classifications criteria. They were evaluated according to an established protocol in order to obtain relevant data about disease history, disease activity and damage accumulated from the beginning of SLE. For this purpose, we obtained immunological profile for all patients; we recorded all relevant laboratory data connected to organ involvement in SLE and applied scores like SELENA-SLEDAI – to evaluate activity - and SLICC/ACR damage index (SDI). In order to be able to apply SDI to all patients, one of the inclusion criteria was the disease older then 1 year. All patients had an evaluation of their status for 25(OH) Vitamin D.ResultsStudy group had a female predominance (93.84%), with a mean age of 42.45 [15.859] and a mean disease duration of 8.0 [7.7] years. The mean SELENA-SLEDAI score was 5.37 [3.385]. Mean prednisone equivalent dose was 7.45 [8.38] daily. More then half of the patients (34 from 65) had a SDI equal or more than 1. When compared between the one that already accumulated damage (SDI≥1) with the others, significant differences (p