FRI0281 Predictors of Quality of Life in Behçet's Syndrome

BackgroundQuality of life is commonly impaired in patients with chronic inflammatory diseases. The disease itself as well as the drugs used may be responsible for this impairment. Behçet's syndrome (BS) is a multisystem vasculitis with a wide variety of manifestations including oral ulcers, genital ulcers, nodular lesions, papulopustular lesions, arthritis, uveitis, venous thrombosis, arterial aneurysms, neurologic and gastrointestinal involvement. Determining the factors affecting quality of life in BS patients, would help developing effective management strategies.ObjectivesWe aimed to determine the factors that impair quality of life (QoL) in BS.MethodsShort- Form 36 (SF-36) physical component score (PCS) and mental component score (MCS) and Behçet Disease Quality of Life (BDQoL) questionnaires were filled by consecutive BS patients attending our outpatient clinic. Socioeconomic factors, each type of organ involvement during the disease course, during the last 4 weeks, disabilities caused by each, treatment modalities and overall disease activity were tested with regression analysis as possible determinants of QoL.Results453 patients (M/F: 240/213, mean age: 38.2±10.8) were included in our study. 223 patients had eye involvement, 94 patients had vascular involvement, 102 patients had joint involvement, 28 patients had neurologic involvement, 2 patients had gastrointestinal involvement and 127 patients had only mucocutaneous involvement without organ involvement. Determinants of BDQoL in the whole group were BSAS, household income, perceived sufficiency income, neurologic damage, mucocutaneous involvement (R2: 0.38, p