FRI0462 Does Serum NT-Probnp Test Facilitate Diagnosis of PAH in Patients with SSC?

BackgroundPulmonary arterial hypertension (PAH) is a progressive vasculopathy that is advanced by the time symptoms develop. Screening can help; however, multiple investigations, including annual echocardiography, DLCO etc., have low specificity and may not be cost-effective.ObjectivesWe sought to evaluate the predictive level and accuracy of serum N-terminal pro-brain natriuretic peptide (NT-proBNP) in a screening for SSc-PAH.MethodsWe studied 65 SSc patients with various forms of PH and 25 SSc patients without PH, confirmed by right heart catheterization (RHC). SSc was diagnosed in accordance with EULAR/ACR criteria (2013). Demographics studies, physical examination, vital signs measurement, 6-minute walk test, echocardiography, pulmonary function testing, and biomarker levels (N-terminal pro-brain natriuretic peptide [NT-proBNP] and uric acid) were done within 24 hours before RHC. We got 4 groups of patientsResultsSSc-PAHPH-LHD (left heart diseases)PH-ILD (interstitial lung disease)SSc without PHN, pts528525Age, year51,6±14.153,0±16,660,0±4.153,4±11,7mPAP, mm Hg48±1131±629±316±4NT-proBNP, pg/ml1070 (353; 4096)1259 (403; 2297)112 (62; 430)*113 (46; 178)* Age differences were not significantly. NT-proBNP levels didn't differ in groups PAH-SSc and PH-LHD, and were significantly higher than in other groups (* - p252,5 pg/mL, predicts the presence of SSc-PAH with sensitivity of 82% and specificity of 72%; positive predictive value for SSc-PAH was 86,6%, negative predictive value – 72,4%; risk of PAH was 3.66-fold higher than for other forms PH (95%CI 1.45; 9,21) (p=0.0059). Hazard ratio for PH-LHD was 4.99 (95% CI 0.61;40,59). Unfortunatelly, this fact was not significant (p=0.13).ConclusionsIncreased serum NT-proBNP can be considered as detecting factor of SSc-PAH provided left heart diseases are excluded.Disclosure of InterestNone declared