AB0275 One-Year Treatment Patterns and Healthcare Resource Use Among Patients with Rheumatoid Arthritis Newly Initiating Treatment with Biologic Dmards

BackgroundBiologic DMARDs (bDMARDs) are used to treat patients (pts) with moderate to severe rheumatoid arthritis (RA). Pts may experience clinical benefits from treatment with bDMARDs alone or with a conventional synthetic DMARD (csDMARD).ObjectivesTo assess treatment patterns and healthcare resour...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Annals of the rheumatic diseases 2015-06, Vol.74 (Suppl 2), p.984
Hauptverfasser: Harnett, J., Gerber, R., Gruben, D., Wiederkehr, D., Mahgoub, E.Y., Wallenstein, G., Koenig, A.
Format: Artikel
Sprache:eng
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:BackgroundBiologic DMARDs (bDMARDs) are used to treat patients (pts) with moderate to severe rheumatoid arthritis (RA). Pts may experience clinical benefits from treatment with bDMARDs alone or with a conventional synthetic DMARD (csDMARD).ObjectivesTo assess treatment patterns and healthcare resource use (HCRU) after prescription/administration of a bDMARD alone or with a csDMARD.MethodsIn this retrospective cohort analysis, pts aged ≥18 years (yrs) with an RA diagnosis (ICD9: 714.xx) who were prescribed/administered a DMARD (2007–2011) were selected from de-identified US electronic health records (EHR; Humedica). Index date was date of first prescription/administration for a bDMARD (adalimumab, certolizumab, etanercept, golimumab, infliximab, rituximab, anakinra, tocilizumab). Pts did not receive bDMARDs for ≥6 months pre-index and were followed for ≥1 yr post-index. Pts were classified by index biologic monotherapy (Bmono) or combination therapy with bDMARD and csDMARD (B+CScombo; based on methotrexate, leflunomide, sulfasalazine, hydroxychloroquine at index). Regression analyses for switch (new bDMARD/csDMARD prescription/administration and no index drug for ≥120 days) and RA-related costs were assessed controlling for differences in pt demographics/characteristics. RA-related costs were derived from a pt subset with linked Optum claims data and applied to RA visits and pharmacy use in EHR.ResultsOf 2119 pts initiating a bDMARD, 70.6% received Bmono and 29.1% received B+CScombo; 0.2% had ≥2 biologics. Pt characteristics and treatment patterns are presented in Table 1. Mean age and percentage of females were similar for Bmono and B+CScombo pts. Compared with B+CScombo pts, Bmono pts were more likely to be treated by a rheumatologist, had a higher Deyo-Charlson Co-morbidity Index score and were more likely to have cardiovascular disease, hyperlipidaemia, hypertension and renal disease. Most Bmono and B+CScombo pts were prescribed a TNF inhibitor (TNFi). During 1-yr follow-up (FU), B+CScombo pts were less likely to switch index regimen vs Bmono pts (OR 0.37; 95% CI 0.27, 0.51; p
ISSN:0003-4967
1468-2060
DOI:10.1136/annrheumdis-2015-eular.3650