THU0012 Observing Dysregulation of Signal Transduction Genes in the WNT Pathway Using two Methods
BackgroundIn recent years, the morphogen pathways (1), and specifically the Wnt pathway has been implicated in the development of fibrosis in Systemic Sclerosis (SSc) (2). Animal studies have shown that dysregulation frizzled related protein (FRZB) (3), frizzled class receptor 4 (FZD4) (4) and secre...
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| Veröffentlicht in: | Annals of the rheumatic diseases 2015-06, Vol.74 (Suppl 2), p.197 |
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| Hauptverfasser: | , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Online-Zugang: | Volltext |
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| Zusammenfassung: | BackgroundIn recent years, the morphogen pathways (1), and specifically the Wnt pathway has been implicated in the development of fibrosis in Systemic Sclerosis (SSc) (2). Animal studies have shown that dysregulation frizzled related protein (FRZB) (3), frizzled class receptor 4 (FZD4) (4) and secreted frizzled related protein 1 (SFRP1) (5) have been implicated in the pathogenesis of SSc.ObjectivesExamine differential gene expression and methylation status of 84 genes in the Wnt pathway.MethodsSkin biopsies were taken from 8 black South African patients with early ( |
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| ISSN: | 0003-4967 1468-2060 |
| DOI: | 10.1136/annrheumdis-2015-eular.4452 |