Design and development of macrocyclization methods for compounds with potential tuberculocidal activity to decrease CYP450 liver cytochrome inhibition

Design and development of macrocyclization methods for compounds with potential tuberculocidal activity to decrease CYP450 liver cytochrome inhibition

A procedure for macrocyclization of compounds with potential tuberculocidal activity was developed in order to obtaining compounds with a lower degree of inhibition of the key CYP 3A4 cytochrome.

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Bibliographische Detailangaben
Veröffentlicht in:Russian journal of general chemistry 2017-04, Vol.87 (4), p.717-730
Hauptverfasser: Vasilevich, N. I., Aksenova, E. A., Aksenova, A. A., Afanasyev, I. I.
Format: Artikel
Sprache:eng
Schlagworte:
Chemistry
Chemistry and Materials Science
Chemistry/Food Science
Cytochrome
Liver
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Zusammenfassung:A procedure for macrocyclization of compounds with potential tuberculocidal activity was developed in order to obtaining compounds with a lower degree of inhibition of the key CYP 3A4 cytochrome.
ISSN:1070-3632
1608-3350
DOI:10.1134/S1070363217040107