The synergistic effects of [omega]-3 fatty acids and nano-curcumin supplementation on tumor necrosis factor (TNF)-[alpha] gene expression and serum level in migraine patients

Migraine is a destabilizing neuroinflammatory disorder characterized by recurrent headache attacks. Evidences show tumor necrosis factor (TNF)-[alpha] play a role in neuroimmunity pathogenesis of migraine. TNF-[alpha] increase prostanoid production, hyperexcitability of neurons, and nociceptor activ...

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Veröffentlicht in:Immunogenetics (New York) 2017-06, Vol.69 (6), p.371
Hauptverfasser: Abdolahi, Mina, Tafakhori, Abbas, Togha, Mansoureh, Okhovat, Ali Asghar, Siassi, Feridoun, Eshraghian, Mohammad Reza, Sedighiyan, Mohsen, Djalali, Mona, Mohammadzadeh Honarvar, Niyaz, Djalali, Mahmoud
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Sprache:eng
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Zusammenfassung:Migraine is a destabilizing neuroinflammatory disorder characterized by recurrent headache attacks. Evidences show tumor necrosis factor (TNF)-[alpha] play a role in neuroimmunity pathogenesis of migraine. TNF-[alpha] increase prostanoid production, hyperexcitability of neurons, and nociceptor activation resulted in neuroinflammation and neurogenic pain. [omega]-3 fatty acids and curcumin exert neuroprotective and anti-inflammatory effects via several mechanisms including suppression of TNF-[alpha] gene expression and its serum levels. The aim of this study is an evaluation of synergistic effects of [omega]-3 fatty acids and nano-curcumin on TNF-[alpha] gene expression and serum levels in migraine patients. The present study performed as a clinical trial over a 2 month period included 74 episodic migraine patients in 4 groups and received [omega]-3 fatty acids, nano-curcumin, and combination of them or placebo. At the start and the end of the study, the gene expression of TNF-[alpha] and TNF-[alpha] serum levels was measured by real-time PCR and ELISA method, respectively. Our results showed that the combination of [omega]-3 fatty acids and nano-curcumin downregulated TNF-[alpha] messenger RNA (mRNA) significantly in a synergistic manner (P < 0.05). As relative to gene expression, a significant greater reduction in serum levels of TNF-[alpha] were observed in the combination group, but no significant differences in other groups. Supplementation with [omega]-3 fatty acids or nano-curcumin alone did not show significant reduction either in mRNA or serum levels of TNF-[alpha]. In addition, a much greater reduction in attack frequency was found in the combination group (P < 0.001). These findings indicated that [omega]-3 fatty acids and curcumin supplementation can be considered as a new promising approach in migraine management.
ISSN:0093-7711
1432-1211
DOI:10.1007/s00251-017-0992-8