Effect of Solid Dispersions on the Dissolution of Ampicillin

In this work, we studied water solubility of ampicillin trihydrate and its solid dispersions (SD) with polyethylene glycol-1500, polyvinylpyrrolidone-10000, and β-cyclodextrin. It was found that SD formation increases the solubility by a factor of 1.34–1.73 and the rate of ampicillin dissolution by...

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Veröffentlicht in:	BioNanoScience 2017-06, Vol.7 (2), p.340-344
Hauptverfasser:	Krasnyuk, I. I., Beliatskaya, A. V., Stepanova, O. I., Korol, L. A., Valeeva, A. M., Grikh, V. V., Ovsyannikova, L. V., Kosheleva, T. M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Ampicillin Antibiotics Biological and Medical Physics Biomaterials Biophysics Circuits and Systems Cyclodextrins Dispersions Dissolution Engineering Nanotechnology Polyethylene glycol Polyvinylpyrrolidone Solubility Solubilization β-Cyclodextrin
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Beschreibung
Zusammenfassung:	In this work, we studied water solubility of ampicillin trihydrate and its solid dispersions (SD) with polyethylene glycol-1500, polyvinylpyrrolidone-10000, and β-cyclodextrin. It was found that SD formation increases the solubility by a factor of 1.34–1.73 and the rate of ampicillin dissolution by a factor of 3.43–7.40. The results of complex physicochemical studies suggest that the improved release of ampicillin from SD is due to its micronization and solubilization by the polymer.
ISSN:	2191-1630 2191-1649
DOI:	10.1007/s12668-016-0342-6