GGPS1 Mutation and Atypical Femoral Fractures with Bisphosphonates: Letter

GGPS1 Mutation and Atypical Femoral Fractures with Bisphosphonates: Letter

This letter describes the detection of GGPS1 and other mutations in three sisters who had atypical femoral fractures associated with long-term bisphosphonate use, which suggests that genes in the isoprenoid biosynthetic pathway may confer susceptibility to atypical fractures.

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Veröffentlicht in:The New England journal of medicine 2017-05, Vol.376 (18), p.1794-1795
Hauptverfasser: Roca-Ayats Neus, Balcells Susana, Garcia-Giralt, Natàlia, Falcó-Mascaró Maite, Martínez-Gil, Núria, Abril, Josep F, Urreizti Roser, Dopazo Joaquín, Quesada-Gómez, José M, Nogués Xavier, Mellibovsky Leonardo, Prieto-Alhambra, Daniel, Dunford, James E, Javaid, Muhammad K, Graham, Russell R, Grinberg, Daniel, Díez-Pérez Adolfo
Format: Artikel
Sprache:eng
Schlagworte:
Drug use
Fractures
Genes
Legs
Mutation
Pharmaceuticals
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Beschreibung
Zusammenfassung:This letter describes the detection of GGPS1 and other mutations in three sisters who had atypical femoral fractures associated with long-term bisphosphonate use, which suggests that genes in the isoprenoid biosynthetic pathway may confer susceptibility to atypical fractures.
ISSN:0028-4793
1533-4406
DOI:10.1056/NEJMc1612804