Association of measured platelet reactivity with changes in P2Y12receptor inhibitor therapy and outcomes after myocardial infarction: Insights into routine clinical practice from the TReatment with ADP receptor iNhibitorS: Longitudinal Assessment of Treatment Patterns and Events after Acute Coronary Syndrome (TRANSLATE-ACS) study

Association of measured platelet reactivity with changes in P2Y12receptor inhibitor therapy and outcomes after myocardial infarction: Insights into routine clinical practice from the TReatment with ADP receptor iNhibitorS: Longitudinal Assessment of Treatment Patterns and Events after Acute Coronary Syndrome (TRANSLATE-ACS) study

Background Little is known about the use of platelet function testing to guide choice of P2Y12receptor inhibitor therapy in routine clinical practice. Methods We studied 671 myocardial infarction (MI) patients treated with percutaneous coronary intervention in the TRANSLATE-ACS Registry who had Veri...

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Veröffentlicht in:The American heart journal 2017-05, Vol.187, p.19
Hauptverfasser: Bagai, Akshay, Peterson, Eric D, McCoy, Lisa A, Effron, Mark B, Zettler, Marjorie E, Stone, Gregg W, Henry, Timothy D, Cohen, David J, Schulte, Phillip J, Anstrom, Kevin J, Wang, Tracy Y
Format: Artikel
Sprache:eng
Schlagworte:
Acute coronary syndromes
Adenosine diphosphate
Antiplatelet therapy
Bleeding
Blood platelets
Cardiovascular disease
Cerebral infarction
Clinical outcomes
Clopidogrel
Consortia
Heart attacks
Hospitalization
Inhibitor drugs
Inhibitors
Intervention
Ischemia
Myocardial infarction
Patients
Population
Reactivity
Stroke
Switching
Therapy
Thrombosis
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Zusammenfassung:Background Little is known about the use of platelet function testing to guide choice of P2Y12receptor inhibitor therapy in routine clinical practice. Methods We studied 671 myocardial infarction (MI) patients treated with percutaneous coronary intervention in the TRANSLATE-ACS Registry who had VerifyNow platelet function testing performed while on clopidogrel treatment during their index hospitalization (April 2010-October 2012). Results High platelet reactivity (>208 platelet reactivity units [PRU]) was present in 261 (38.9%) patients. Clopidogrel was switched in-hospital to prasugrel in 80 (30.7%) patients with high platelet reactivity and 18 (4.4%) patients with therapeutic platelet reactivity (
ISSN:0002-8703
1097-6744
DOI:10.1016/j.ahj.2017.02.003