Synthesis and Biological Activity of 1,11-bis(6,7-Methylenedioxy- and 6,7-Dimethoxy-1,2,3,4-Tetrahydroisoquinolin-1-YL)Undecanes

Synthesis and Biological Activity of 1,11-bis(6,7-Methylenedioxy- and 6,7-Dimethoxy-1,2,3,4-Tetrahydroisoquinolin-1-YL)Undecanes

Two bis(tetrahydroisoquinoline) derivatives of undecane were synthesized from brassylic acid and 3,4-dimethoxy-(or methylenedioxy-)phenylethylamine. It was shown that 4a and 4b were highly cytotoxic for cancer-cell cultures and less toxic to healthy cells and exhibited noticeable antimicrobial activ...

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Veröffentlicht in:Chemistry of natural compounds 2017, Vol.53 (2), p.328-332
Hauptverfasser: Terent′eva, E. O., Saidov, A. Sh, Khashimova, Z. S., Tseomashko, N. E., Sasmakov, S. A., Abdurakhmanov, D. M., Vinogradova, V. I., Azimova, Sh. S.
Format: Artikel
Sprache:eng
Schlagworte:
Bacteria
Biological activity
Fungi
Fungicides
Medicine
Organic Chemistry
Pharmacy
Phenylethylamine
Plant Sciences
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Zusammenfassung:Two bis(tetrahydroisoquinoline) derivatives of undecane were synthesized from brassylic acid and 3,4-dimethoxy-(or methylenedioxy-)phenylethylamine. It was shown that 4a and 4b were highly cytotoxic for cancer-cell cultures and less toxic to healthy cells and exhibited noticeable antimicrobial activity against Gram-positive and Gram-negative bacteria and fungal strain Candida albicans. The antifungal activity of 4a exceeded that of the reference drug nystatin.
ISSN:0009-3130
1573-8388
DOI:10.1007/s10600-017-1981-8